Stilbenoid compounds inhibit NF-κB-mediated inflammatory responses in the Drosophila intestine

Introduction Stilbenoid compounds have been described to anti-inflammatory properties in animal models vivo , and shown inhibit Ca2+-influx through the transient receptor potential ankyrin 1 (TrpA1). Methods To study how stilbenoid affect inflammatory signaling we utilized fruit fly, Drosophila melanogaster as a model system. induce intestinal inflammation fed flies with irritant dextran sodium sulphate (DSS). Results We found that DSS induces severe changes bacteriome of intestine, this dysbiosis causes activation NF-κB transcription factor Relish. taken advantage DSS-model pinosylvin (PS) monomethyl ether (PSMME). With help approaches, identified PS PSMME be (TrpA1)-dependent antagonists NF-κB-mediated immune responses . also computationally predicted putative antagonist binding sites these at TrpA1. Discussion Taken together, show stilbenoids intestine can used alleviate chemically induced